How should we understand goal-oriented behavior and the evolution of function across diverse living systems? Professor Alan Love is leading a new global cohort program that seeks to articulate more precise concepts, develop innovative formal models and accurate measurement methods, and foster new scientific research related to purposiveness in living systems. The three-year effort includes 24 projects from across the globe.
Using the examples of gastrulation, somitogenesis, and limb skeletal development, this chapter provides instances of, and a conceptual framework for understanding, the relationships between physical and evolved types of developmental self-organization. Stuart A. Newman writes in Quantitative Biology.
This mutational hypothesis offers to explain both evolutionary parallelism and recurrence in disease of gene fusions under one umbrella. Here, we test this hypothesis using bioinformatic data. Evgeni Bolotin, Daniel Melamed, and Adi Livnat write in bioRxiv.
This paper has three aims: first, to analyse the organisational conditions and the physiological mechanisms that enable integration in prokaryotic associations; second, to discuss the organisational differences between biofilms and prokaryotic endosymbiosis and the types of integration they achieve; finally, to provide a more precise account of functional integration based on these case studies. Guglielmo Militello, Leonardo Bich and Alvaro Moreno write in Acta Biotheoretica.